Perhaps Republic Apartments Brisbane greatest asset is its location, offering quality hotel accommodation in Brisbane CBD and near Queen Street Mall, near Chinatown, trendy Spring Hill and the Brisbane River. Also, near Wickham Terrace.

Republic Apartments Brisbane is a quick 15-minute taxi ride from Brisbane Airport or a few minutes walk from Central Rail Station and Roma Street Station. A 12-minute walk to the RNA or Ekka Showgrounds. Also near several hospitals including the Brisbane Dental Hospital, Brisbane Dental College, Royal Children's Hospital, the Holy Spirit Hospital, the Mater Private Hospital and Pricess Alexandra Hospital (the PA Brisbane).

Also near the Royal Brisbane Hospital & Women's Hospital, near Brisbane Private Hospital and near the Queensland Eye Hospital. St Andrew's Hospital at the top of Wickham Terrace, in Spring Hill is a 5-minute Taxi ride away.