Hotel Plaza San Francisco Santiago is located on the capital's most important avenue -Libertador Bernardo O'Higgins, commonly referred to as "La Alameda", which is Santiago's main artery. This wide avenue allows quick and easy access to the city's international airport located only 10 miles (16 kilometers) away. The hotel is also just steps away from the most important financial district in the country providing an outstanding alternative for the guests to visit the Chilean "Wall Street", home to large national and international businesses and conventions.

Hotel Plaza San Francisco Santiago enjoys a privileged location in the heart of downtown Santiago only 10 miles (16 kilometers) from the Santiago International Airport. A mere 25 miles (40 kilometers) away or an hour's drive away, is the Andes Mountains where it is possible to enjoy winter skiing and other mountain activities. The major beaches and vacation spots - Vina del Mar and Valparaiso - are only 75 miles (120 kilometers) away; or less than 2 hours by car.