The Othon Palace Belo Horizonte is centrally located in downtown Belo Horizonte at 1050 Avenida Afonso Pena, directly opposite Municipal Park and right by Liberdade Square (Praça da Liberdade). The hotel is located approximately 25 kilometres (20 minutes) from Pampulha Airport (PLU) airport and 38 kilometres (45 minutes) from Tancredo Neves (CNF) airport.

The Othon Palace Belo Horizonte is surrounded by excellent shopping malls, upmarket boutiques, many cafes and restaurants, theaters such as the Palacio des Artes, and the Cultural Center and Central Market. Palacio da Liberdade, Boa Viagem Cathedral, the Church of Sao Josethe Praca da Estacao (Station Square) and Sete de Setembro Square are all within easy walking distance.

With its interesting juxtaposition of contemporary and classical buildings, Belo Horizonte boasts many of Brazil's modern architectural icons, most notably the Chapel of Sao Francisco de Assis (Igreja de Pampulha) designed by renowned Brazilian, modernist architect Oscar Niemeyer and decorated by Candido Portinari.