Novotel Toronto Center is located in downtown Toronto, within walking distance of many attractions such as the Air Canada Centre, the Hockey Hall of Fame, Rogers Centre, the Harbourfront Centre, the Eaton Centre, St. Lawrence Market, Centre Island ferry docks, the financial district and Union Station.

From Pearson International Airport or Highway 401 Eastbound, exit onto Highway 427 South. Exit Highway 427 onto the Gardiner Expressway (after about 20 minutes). Exit the Gardiner Expressway onto Yonge Street North. Immediately after turning onto Yongestreet, there will be an overpass. Immediately after the overpass turn right onto The Esplanade. The Novotel Toronto Center is after the stop sign on the right hand side.