Mercure Brisbane is only 15 kilometres to both the international and domestic airports and a short drive to many of Queensland's attractions. Alternatively, Mercure Brisbane is close to the Roma Street transit centre, city cat / ferry stops, and several bus stops. Situated on the banks of the Brisbane River with panoramic views over Southbank Parklands and the Performing Arts Complex Easily accessible on North Quay.

Many inner city attractions are just a short walk or drive from Mercure Brisbane including Treasury Casino, South Bank Parklands (restaurants/markets/beach), Botanical Gardens, Kangaroo Point Cliffs, Roma Street Parklands, Queen Street Shopping Mall, Toowong Shopping Centre and many more.