Crowne Plaza London-Docklands Hotel is located in the heart of London's dynamic Docklands area, overlooking Royal Victoria Dock with its sailing and windsurfing school. The hotel is just minutes from the financial district of Canary Wharf and the City of London and is the only Crowne Plaza hotel in London's Docklands. London City Airport is a short ride away by bus or taxi, and the hotel can be reached with no difficulty from London Stansted Airport via Liverpool Street Station.

The hotel is easily reached by rail to Royal Victoria Station on the Docklands Light Railway system, only a five-minute walk from the hotel entrance. The hotel can be reached by tube via the Jubilee Line to Canning Town, with a short onward connection via the Docklands Light Railway. If travelling by car, you can find the hotel easily from the M25 and M11 by following the signs for London City Airport and then ExCeL West. The hotel also offers a free courtesy coach between the hotel and Canary Wharf Monday to Friday.